Uses of Ciprofloxacin

Ciprofloxacin is used in the treatment of various bacterial infections such as pharyngitis, tonsillitis, pneumonia, sinusitis, ear infections, urinary tract infections, genital tract infections, stomach infections, infections of bones and joints and skin and soft tissue infections. It can also be used in the management of patients with anthrax inhalation exposure.

Therapeutic Category

Ciprofloxacin: Fluoroquinolone antibiotics

How Ciprofloxacin works

Ciprofloxacinworks by blocking the actions of certain bacterial proteins (such as DNA gyrase, topoisomerase IV) which is essential for the bacteria to survive. As a result, it destroys the susceptible bacteria and prevent their further growth and multiplication within the body which helps in reducing the severity of the infection.

When to consult your doctor

Consult your doctor if you experience:

• impairment of vision, taste and smell and hearing, depression, memory impairment, severe fatigue and severe sleep disorders
• severe allergic reaction with symptoms such as tightness in the chest, feeling dizzy, feeling sick, faint, and experience dizziness while standing
• impairment of eyesight, taste, smelling, hearing
• pain and swelling of tendons (Ex. in your ankle, wrist, elbow, shoulder or knee), difficulty in walking
• rapid irregular heartbeat
• fits, neurological disease, psychosis, nerve pain, painful urination, presence of crystals in urine

be

Older for kidney problems

Health Tips for Ciprofloxacin

• Taking Ciprofloxacin with antifungal medication, like ketoconazole and itraconazole, can cause potential drug resistance and impaired bacterial metabolism
• Ciprofloxacin can also lead to increased production of the enzyme topoisomerase IV which is responsible for some of the DNA gyrase and gyrase inhibitors (KAI) (Rupto Regraft n Ciprofloxacin) which is responsible for some of the DNA gyrase and topoisomerase IV (Ketoprofen) (Rxnd) which is the combination of these enzymes
• Ciprofloxacin can also cause an increased risk of serious allergic reactions, including an the development of rashes, hives, swelling and difficulty of breathing which should stop after you take it
• Taking Ciprofloxacin with certain medications (e.g. anti-epigastrotitis medications) can make it more likely for the bacteria to regain balance, become more susceptible to sunlight and other direct stress rays, which can lead to kidney problems

How long does it take for Ciprofloxacin to work?

Ciprofloxacin typically starts to work within 1-2 hours of taking a dose and itraconazole 1-2 days after. It can take up to 2-3 days for the full therapeutic effect and sometimes the full effects can be experienced after a relatively low dose. The doses may vary depending on your age, the severity of your viral infections and your age and your ethnic group.

Can I drink alcohol while taking Ciprofloxacin?

It is recommended to avoid excessive drinking of alcohol as it can increase the risk of side effects.

It is important to let your doctor know about any medications you are taking before starting Ciprofloxacin which could lead to side effects.

Men who are at increased risk for male sexual dysfunction

Ciprofloxacin is not suitable for use in women or children.

How often should I take Ciprofloxacin?

FREQUENTLY as prescribed by the doctor.

Extemetron treatment

Uses of Ciprofloxacin+Tinidazole

The combination of Ciprofloxacin and Tinidazole is indicated for the management of a wide variety of infections caused by susceptible gram-positive and gram-negative organisms along with anaerobes and protozoa.

Therapeutic Category

Ciprofloxacin: Antibiotics (Quinolone antibiotics)

Tinidazole : Antiprotozoals

How Ciprofloxacin+Tinidazole works

Ciprofloxacin + Tinidazole effectively manages infection, where ciprofloxacin works by killing bacteria that cause infections. It only works with specific strains of bacteria. Tinidazole works by killing the parasites and anaerobic bacteria that are responsible for causing infections by damaging their DNA.

Common side effects of Ciprofloxacin+Tinidazole

• diarrhoea
• joint pain and inflammation
• nausea, vomiting
• loss of appetite
• stomach pain or cramps
• headache
• vertigo (head spinning sensation)
• skin rash or itching (especially affecting the whole body)

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience severe, sudden allergic reaction with symptoms such as tightness in the chest, feeling dizzy, sick or faint or experience dizziness when standing up
• If you experience muscle weakness, inflammation of the tendons which could lead to rupture of the tendon, particularly affecting the large tendon at the back of the ankle
• If you experience serious life-threatening skin rash, usually in the form of blisters or ulcers in the mouth, throat, nose, eyes and other mucous membranes such as genitals which may progress to widespread blistering or peeling of the skin (stevens-jhonson syndrome, toxic epidermal necrolysis

Health Tips for Ciprofloxacin+Tinidazole

• Take Ciprofloxacin + Tinidazole exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor
• Do not eat or drink any dairy products (such as milk or yoghurt) or drinks with added calcium when you take Ciprofloxacin + Tinidazole, as they may affect the absorption of this medicine. Also, do not drink wine, beer or spirits during treatment and for 3 days after stopping treatment with this medicine. Remember to drink plenty of fluids while you are taking this medicine
• Avoid consumption of alcohol while taking Ciprofloxacin + Tinidazole
• Do not drive or operate any machines while taking Ciprofloxacin + Tinidazole as it may make you feel less alert and cause neurological problems
• Ciprofloxacin + Tinidazole should not be taken during pregnancy and during breastfeeding and for three days following the last dose as it may passes through breast milk
• Ciprofloxacin + Tinidazole is not recommended for use in individuals with blood disorder or a history of blood disorders and peripheral neuropathy

Do not take do not stop you taking this medicine without first consulting your doctor. If you experience any serious side effects, contact your doctor immediatelyAdd NEW MEDICINE

Ciprofloxacin + Tinidazole Dosage: Updated Info

Ciprofloxacin + Tinidazole should be taken at the same time each day. The dosages will vary from patient information to about 500mg per day, which is approximately the amount you would need for a single treatment. The old ‘Tinidazole advice to take twice a day’, ‘Twice a day dosage’ and ‘Dosage instructions for children’ dosages were only available in 2011. New information has come to light about how to take ciprofloxacin + Tinidazole, including how to ensure that you are taking this medicine safely and effectively.

Indications

Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.

Administration

May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.

Contraindication

Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.

Common side-effects

Vomiting, Stomach pain, Nausea, Diarrhea

Special Precaution

Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.

Storage

Store between 20-25°C.

MedsGo Class

Quinolones

Drivers of visionlights:

Caution in patients with diabetes, recent stroke, or diabetic ketoacidosis, or diabetic retinopathy, caution in patients taking quinolone therapy, or those taking other non-prescription oral antidiabetic agents.

Patients with a history of muscle disorders (e.g. stroke or myasthenia gravis), seizures, liver enzyme elevation, anticholinergic medication, hypotension, recent cardiac surgery, or uncontrolled blood pressure should discuss the muscle disorders and the quinolone otic agent with their physician before using CNS decoquil. Avoid the use of CNS decoquil in patients with high blood pressure and other hypotensive disorders. CNS decoquil should not be used in patients with diabetes, who are hypertensive, or with certain heart conditions, when other oral antidiabetic agents may increase risk.

Monoamine Oxidase Inhibitors

Therapy should be started in the presence of clinical worsening or laboratory evidence of toxicity.

Permanent�ciprofloxacin+tizanidine+dapsone+amitryptoferrin

Pregnancy

The safety of the use of Ciprofloxacin has not been established in pregnancy. Ciprofloxacin is not indicated for pregnant patients, due to the potential for toxicity. Posological factors include serum calcium levels, liver function tests, and positive fluid/collision studies. Dose reduction with Ciprofloxacin administration has not been studied during the first trimester. The maximum daily dose is up to 2400 mg. Due to potential for acute ototoxicity, patients should be carefully monitored while using Ciprofloxacin. Discontinue if adverse events persist or worsen.

Non-persistent decreased liver function

Interactions

May increase levels of serum potassium, resulting in significant and potentially irreversible toxicity (e.g. hypotension, electrolyte disturbances, seizures). Potassium-sparing diuretics such as Risperidone and BUNOWER (astemizole) should be used with caution. May enhance the therapeutic effect of Ciprofloxacin by inhibiting calcium channels. May impair the effectiveness of diuretics such as Risperidone and BUNOWER (amitryptoferrin).

Indications

Ciprofloxacin is for use by the gums only.

Adult Dose

Oral: 10 mg/kg kg b.i.d. for 3 consecutive days, then 20 mg/kg b.i.d. for 3 consecutive days. Increase to 40 mg/kg b.i.d. if clinically clinically appropriate. If no clinical response is observed 3 days later. Increase to 2 g/kg b.i.d. if clinically appropriate. If no clinical response is observed for more than 4 days, or if clinical signs and symptoms occur more than 4 days later.Renal Function:Gastrointestinal: Hemodialysis for 2 h. Do not exceed 20 mg/kg b.i.d. If no effect is observed for more than 4 days. (See Use in patients with impaired renal function and impaired hepatic function).

Pediatric Dose

Oral: 10 mg/kg b.i.d.

Renal Function

Renal function is evaluated according to the modified Renal Impairment Score (mRIS) test, with 5-HT and androgen binding globulin (UgG), and to creatinine clearance (CrCl). CrCl is calculated as the sum of the upper and lower end-expiratory blood markers. If there is no clinical response, a starting dose of 10 mg/kg b.i.d. is used. If the clinical response is inadequate, a starting dose of 20 mg/kg b.i.d. If CrCl is within 5% the dose is 20 mg/kg b.i.d.

Administration

May be taken with or without food.

Contraindications

Known hypersensitivity to ciprofloxacin or any of the excipients. Unnecessary use of the drug.

Special Precautions

Renal function should be monitored throughout treatment, even if the patient shows signs of renal impairment. Close monitoring of hepatic function and serum creatinine is important when ciprofloxacin is used in patients with impaired renal function.

Pregnancy

See the section in the full prescribing information for full drug and alcohol restrictions.

Breast feeding studies in rats, rabbits and monkeys.

Interaction

Increased serum levels of anticoagulant effects.Decreased clearance of the drug and reduced efficacy at a dose of 10 mg/kg b.i.d., when given in the last few days of pregnancy.

Renal Impairment

Ciprofloxacin is associated with abnormalities of renal function in some patients, including patients with impaired renal function, a decreased CrCl and impaired hepatic function. There is evidence that ciprofloxacin may have a role in the treatment of severe and occasionally fatal renal failure, and that ciprofloxacin is associated with a reduction in serum creatinine.

Renal function is evaluated according to the mRIS test, with 5-HT and androgen binding globulin (UgG), and to creatinine clearance (CrCl). If CrCl is within 5% the dose is 10 mg/kg b.i.d.

Adverse Effects

Side effects are rare, but may include: constipation, diarrhea, drowsiness, and fatigue; increased appetite and weight gain; headache; diarrhea, asthenia, urticaria, photosensitivity, tinnitus, dizziness; nausea; vomiting, dry mouth, constipation, diarrhea, and dizziness; palpitations. If any of these effects occur, discontinue therapy.